Jean wouldn't reveal who the character and told Canadian Sun Times, "I'll give you a clue that the actor playing the character won an Emmy for playing that character, but I won't say who it is."
Jean also revealed the the last episode in the season would see a crossover with Futurama saying, "I've been here 25 years, and we had a read yesterday where the excitement was as high as I've ever seen. We had John DiMaggio and Billy West and (Canadian voice-over king) Maurice LaMarche from Futurama, as well as our cast, and I thought that's got to be the greatest voiceover talent assembled at one read. It was really, really great to see Bender interacting with Homer."
It's been quite some time since The Simpsons killed off a major character with it being 14 years since Maude Flanders died, and although there will be upset people no matter who's chosen it's about time that they did something as dramatic as this. Now the hint doesn't really add much help as a lot of The Simpsons voice talent have won awards over the years. I personally think it's going to be Sideshow Bod, but if it's not it could be someone closer to home like Grampa or even possibly the Comic Book Guy who's to be wed this season. It could however be anyone as the only characters that are sure to be safe are the main family.